國家圖書館 期刊文獻資訊網

連結國家圖書館 連結期刊文獻資訊網

臺灣期刊論文索引

摘要

本篇出處 臺灣兒科醫學會雜誌 48:2 2007.03-04[民96.03-04] 頁57-61+96
篇名 Evaluation of Biological Features of Cord Blood Units in Different Taiwan Ethnics
作者 詹榮華 ; 溫淑惠 ; 許文林 ; 張宇勳 ; 陳淑惠
中文摘要   背景:臍帶血庫在世界各地的設置,應對於臍帶血移植使用增加一趨勢。相對於傳統骨髓移植,主因臍帶血移植有著較少排斥的現象。但臍帶血移植也有它的限制,如中性球和血小板的定植較慢、免疫系統重建緩慢、抗腫瘤活力不確定、和細胞數的不足等。方怯:本研究主要目的分析花蓮慈濟臍帶血庫中,是否因不同的族群因素,會影響臍帶血的生物特色。我們分析從2001到2006年中,收集1743個臍帶血單位,記錄白血球數、紅血球數、血色素、CD34(上標 +)和臍帶血體積。依據臺灣不同的族群人口,將分為外省、閩南和客家三個人口群,各有149、1367和163個單位。去比較臍帶血之問的生物特色,包括白血球數、紅血球數、血色素值、CD34(上標 +)數目和臍帶血體積。並進一步分別考慮流行病學上重要因子,給予多變項分析。結果:在單項分析發現不同族群問的臍帶血白血球數,紅血球數,血色素值和臍帶血體積,並沒有明顯統計學上的差異。最後僅發現不同的族群,臍帶血CD34(上標 +)數目有明顯統計學上不同。多變項分析中,發現中臺灣人口有較低CD34(上標 +)趨勢。結論:此研究結果顯示,在台灣不同族群分布地區因子,對於臍帶血CD34(上標 +)數目,有其影響的作用。
英文摘要   Background: Cord blood banks are established worldwide as a result of the increased use of umbilical cord blood (UCB) transplantation. The outcomes of this procedure relate to the cell dose of the UCB unit and the UCB collection. The aim of this study was to evaluate whether the differentiation of ethnicity influenced the biological features of the UCB units. Methods: A total of 1743 UCB units were measured for the biological features, including white blood cell count, red blood cell, Hb, CD34(superscript +) and volume of cord blood. Of these, 149 Mainlander, 1367 Hoklo, and 163 Hakka units were selected from the Buddhist Tzu Chi Stem Cell Center Results: The three groups were comparable for biological features of the UCB units. No differences were observed between the different ethnic groups in terms of white blood cell count, red blood cell, Hb, and volume of cord blood, except mean CD34(superscript +) in univariate analysis. However, the mean CD34(superscript +) cells appeared to be lower in Middle Taiwan in trend after adjustment for demographic factors. Conclusions: This preliminary study showed that ethnic distribution factor appeared to affect CB cell yields in Taiwan.